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Review : β 2-Glycoprotein I : Target antigen for 'antiphospholipid' antibodies. Immunological and molecular aspects

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, University of New South Wales, The St George Hospital, Kogarah, New South Wales, Australia

DA Kandiah

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, University of New South Wales, The St George Hospital, Kogarah, New South Wales, Australia

SA Krilis

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, University of New South Wales, The St George Hospital, Kogarah, New South Wales, Australia

It has become clear that β ₂-glycoprotein I (β₂GPI) is the most common and best-characterised antigenic target for 'antiphospholipid' (aPL) autoantibodies. These antibodies preferentially bind β₂GPI that has been immobilised on anionic phospholipid membranes or certain synthetic surfaces. These surfaces appear to act by increasing antigen density to allow binding of intrinsically low- affinity anti-β₂GPI autoantibodies. Binding of β₂GPI in fluid phase is weak and requires high concentrations of β₂GPI. Our understanding of the pathophysiology of the 'Antiphospholipid' Syndrome (APS) has increased exponentially with the number of studies into the interactions of aPL antibodies and β₂GPI.

Key Words: β2-glycoprotein I • antiphospholipid antibodies • lupus anticoagulant antibodies

Lupus, Vol. 7, No. 2 suppl, S5-S9 (1998)
DOI: 10.1177/096120339800700202


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