This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Levy, R. Articles by Porto, L. Search for Related Content PubMed PubMed Citation Articles by Levy, R. Articles by Porto, L. Social Bookmarking                         What's this?

Review : Placental pathology in antiphospholipid syndrome

Disciplina de Reumatologia e Departamentos de Anatomia Patológica e de Histologia e Embriologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

E. Avvad

Disciplina de Reumatologia e Departamentos de Anatomia Patológica e de Histologia e Embriologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

J. Oliveira

Disciplina de Reumatologia e Departamentos de Anatomia Patológica e de Histologia e Embriologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

LC Porto

Disciplina de Reumatologia e Departamentos de Anatomia Patológica e de Histologia e Embriologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

One of the major targets of antiphospholipid antibodies (aPL) is the placenta, the evolution of which during pregnancy has been well documented. Histopathological findings are related to gestational age, and several physiologic and pathologic alterations that occur during its development. The major findings in placentae from aPL positive patients are thrombosis, acute atherosis, a decreased number of syncytio-vascular membranes, increased number of syncytial knots and obliterative arteriopathy. These findings are not specific to the antiphospholipid syndrome (APS) and sometimes do not correlate with the fetal outcome. Histopathological study of placentae may elucidate mechanisms of action of aPL in fetal loss and other obstetric complications. In addition, it may assist in the investigation of the differential diagnosis between APS and pregnancy- induced hypertension. Immunohistochemical studies of local placental proteins contribute to this differential diagnosis.

Key Words: antiphospholipid syndrome • placenta • pre-eclampsia

Lupus, Vol. 7, No. 2 suppl, S81-S85 (1998)
DOI: 10.1177/096120339800700218


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Cervera and J. Balasch Bidirectional effects on autoimmunity and reproduction Hum. Reprod. Update, May 22, 2008; (2008) dmn013v1. [Abstract] [Full Text] [PDF]

				N. C. T. Kong Pregnancy of a lupus patient--a challenge to the nephrologist Nephrol. Dial. Transplant., February 1, 2006; 21(2): 268 - 272. [Full Text] [PDF]