Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (41)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Herrera-Esparza, R
Right arrow Articles by Avalos-Díaz, E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herrera-Esparza, R
Right arrow Articles by Avalos-Díaz, E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 7, No. 3, 154-158 (1998)
DOI: 10.1191/096120398678919949

Renal expression of IL-6 and TNF{alpha} genes in lupus nephritis

R Herrera-Esparza

O Barbosa-Cisneros

R Villalobos-Hurtado

E Avalos-Díaz

Immunotechnology Unit, CBE, UAZ, Guadalupe Zac, 98600, Mexico

These studies were carried out to examine the presence of the inflammatory cytokines IL-6 and TNF{alpha} in kidneys of patients with lupus nephritis as an indicator of their possible role in its pathogenesis. A total of 19 kidney biopsies from patients with type III or IV lupus nephritis were processed by direct immunofluorescence using monoclonal anti-IL-6 and TNF{alpha} antibodies. Local expression of these genes was demonstrated both by in situ hybridization and by reverse transcriptase-PCR amplification of total RNA isolated from kidney tissue. Fifty-two percent of the biopsies exhibited IL-6 and TNF{alpha} deposited along the glomeruli and tubules; in situ expression of these cytokines was demonstrated in 6 biopsies with type IV, and 1 with type III nephritis. Inflammatory cytokines are actively synthesized in the kidneys of patients with lupus nephritis and therefore, may play a role in its pathogenesis.

Key Words: IL-6 • TNF{alpha} • lupus nephritis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 NEJMHome page
A. Rahman and D. A. Isenberg
Systemic Lupus Erythematosus
N. Engl. J. Med., February 28, 2008; 358(9): 929 - 939.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Ryan and G. R. McLemore Jr.
Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R736 - R742.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Y. Hoi, M. J. Hickey, P. Hall, J. Yamana, K. M. O'Sullivan, L. L. Santos, W. G. James, A. R. Kitching, and E. F. Morand
Macrophage Migration Inhibitory Factor Deficiency Attenuates Macrophage Recruitment, Glomerulonephritis, and Lethality in MRL/lpr Mice
J. Immunol., October 15, 2006; 177(8): 5687 - 5696.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Yung, R. C.W. Tsang, Y. Sun, J. K.H. Leung, and T. M. Chan
Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implications on Tubulointerstitial Inflammation in Lupus Nephritis
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3281 - 3294.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
M Aringer and J S Smolen
Cytokine expression in lupus kidneys
Lupus, January 1, 2005; 14(1): 13 - 18.
[Abstract] [PDF]

Home page
 LupusHome page
E Tackey, P E Lipsky, and G G Illei
Rationale for interleukin-6 blockade in systemic lupus erythematosus
Lupus, May 1, 2004; 13(5): 339 - 343.
[Abstract] [PDF]

Home page
 LupusHome page
M Aringer and J S Smolen
Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention
Lupus, May 1, 2004; 13(5): 344 - 347.
[Abstract] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. P. D. LEMA, H. MAIER, E. NIETO, V. VIELHAUER, B. LUCKOW, F. MAMPASO, and D. SCHLONDORFF
Chemokine Expression Precedes Inflammatory Cell Infiltration and Chemokine Receptor and Cytokine Expression during the Initiation of Murine Lupus Nephritis
J. Am. Soc. Nephrol., July 1, 2001; 12(7): 1369 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
H. Schotte, B. Schluter, S. Rust, G. Assmann, W. Domschke, and M. Gaubitz
Interleukin-6 promoter polymorphism (-174 G/C) in Caucasian German patients with systemic lupus erythematosus
Rheumatology, April 1, 2001; 40(4): 393 - 400.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
M Y Karim, G Ruiz-Irastorza, M A Khamashta, and G R. Hughes
Update on therapy -- thalidomide in the treatment of lupus
Lupus, March 1, 2001; 10(3): 188 - 192.
[Abstract] [PDF]

Home page
 LupusHome page
R Segal, M Dayan, H Zinger, and E Mozes
Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNF{alpha} monoclonal antibody and by pentoxiphylline
Lupus, January 1, 2001; 10(1): 23 - 31.
[Abstract] [PDF]

Home page
 Ann Rheum DisHome page
G. S Dean, J. Tyrrell-Price, E. Crawley, and D. A Isenberg
Cytokines and systemic lupus erythematosus
Ann Rheum Dis, April 1, 2000; 59(4): 243 - 251.
[Full Text]