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Renal expression of IL-6 and TNF genes in lupus nephritis

O Barbosa-Cisneros

R Villalobos-Hurtado

E Avalos-Díaz

Immunotechnology Unit, CBE, UAZ, Guadalupe Zac, 98600, Mexico

These studies were carried out to examine the presence of the inflammatory cytokines IL-6 and TNF in kidneys of patients with lupus nephritis as an indicator of their possible role in its pathogenesis. A total of 19 kidney biopsies from patients with type III or IV lupus nephritis were processed by direct immunofluorescence using monoclonal anti-IL-6 and TNF antibodies. Local expression of these genes was demonstrated both by in situ hybridization and by reverse transcriptase-PCR amplification of total RNA isolated from kidney tissue. Fifty-two percent of the biopsies exhibited IL-6 and TNF deposited along the glomeruli and tubules; in situ expression of these cytokines was demonstrated in 6 biopsies with type IV, and 1 with type III nephritis. Inflammatory cytokines are actively synthesized in the kidneys of patients with lupus nephritis and therefore, may play a role in its pathogenesis.

Key Words: IL-6 • TNF • lupus nephritis

Lupus, Vol. 7, No. 3, 154-158 (1998)
DOI: 10.1191/096120398678919949


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