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Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus

School of Nutritional Sciences, The Faculty of Agriculture, The Hebrew University of Jerusalem

M Blank

A Afek

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel

Y Kopilowiz

Institute of Pathology, Sheba Medical Center

D Sklan

Department of Animal Sciences, The Faculty of Agriculture, The Hebrew University of Jerusalem

M E Gershwin

B German

S Yoshida

Division of Rheumatology, Allergy and Clinical Immunology, University of California

Y Shoenfeld

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel

Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE).

Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out.

Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.

Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.

Key Words: Polyunsaturated fatty acids • autoimmune diseases • lupus erythematosus • autoantibodies • nutrition

Lupus, Vol. 7, No. 3, 192-197 (1998)
DOI: 10.1191/096120398678919985


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