This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Reifen, R Articles by Shoenfeld, Y Search for Related Content PubMed PubMed Citation Articles by Reifen, R Articles by Shoenfeld, Y Social Bookmarking                   What's this?

Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus

School of Nutritional Sciences, The Faculty of Agriculture, The Hebrew University of Jerusalem

M Blank

A Afek

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel

Y Kopilowiz

Institute of Pathology, Sheba Medical Center

D Sklan

Department of Animal Sciences, The Faculty of Agriculture, The Hebrew University of Jerusalem

M E Gershwin

B German

S Yoshida

Division of Rheumatology, Allergy and Clinical Immunology, University of California

Y Shoenfeld

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel

Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE).

Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out.

Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.

Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.

Key Words: Polyunsaturated fatty acids • autoimmune diseases • lupus erythematosus • autoantibodies • nutrition

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. HAREL and Y. SHOENFELD Predicting and Preventing Autoimmunity, Myth or Reality? Ann. N.Y. Acad. Sci., June 1, 2006; 1069(1): 322 - 345. [Abstract] [Full Text] [PDF]

				M Petri Diet and systemic lupus erythematosus: from mouse and monkey to woman? Lupus, November 1, 2001; 10(11): 775 - 777. [PDF]

				M Ehrenfeld, M Blank, Y Shoenfeld, and M Hidvegi AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease Lupus, September 1, 2001; 10(9): 622 - 627. [Abstract] [PDF]

				S Suwannaroj, A Lagoo, D Keisler, and R W McMurray Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) Lupus, April 1, 2001; 10(4): 258 - 265. [Abstract] [PDF]

				A Leiba, H Amital, M E Gershwin, and Y Shoenfeld Diet and lupus Lupus, March 1, 2001; 10(3): 246 - 248. [Abstract] [PDF]