This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lhote, F Articles by Guillevin, L Search for Related Content PubMed PubMed Citation Articles by Lhote, F Articles by Guillevin, L Social Bookmarking                         What's this?

Polyarteritis nodosa, microscopic polyangiitis and Churg–Strauss syndrome

Hoôpital Delafontaine, Saint-Denis, France

P Cohen

L Guillevin

Hoôpital Avicenne, Bobigny, France

Polyarteritis nodosa (PAN), first described by Küssmaul and Maier, is a well-known form of necrotizing angiitis whose manifestations are weight loss, fever, asthenia, peripheral neuropathy, renal involvement, musculoskeletal and cutaneous manifestations, hypertension, gastrointestinal tract involvement, and cardiac failure. Recently individualized from PAN, microscopic polyangiitis (MPA) is a systemic vasculitis of small-size vessels whose clinical manifestations are very similar to those of PAN, but it is characterized by the presence of rapidly progressive glomerulonephritis (RPGN), which is nearly constant, and pulmonary involvement usually absent in PAN. Churg–Strauss syndrome (CSS) is a disorder characterized by hypereosinophilia and systemic vasculitis similar to that of PAN and occurring in individuals with asthma and allergic rhinitis. Considering the etiologies of PAN, primary and secondary vasculitides can also be distinguished because PAN can be the consequence of hepatitis B virus (HBV) infection and sometimes of other etiologic agents.

The prognosis of systemic vasculitides has been transformed by corticosteroids that are, except in HBV-related PAN, the basic treatment. Immunosuppressive drugs, especially cyclophophamide, have also contributed to improving the prognosis, but their precise role in the management of these vasculitides is still being elucidated.

Key Words: polyarteritis nodosa • microscopic polyangiitis • Churg–Strauss syndrome • corticosteroids • cyclophophamide

Lupus, Vol. 7, No. 4, 238-258 (1998)
DOI: 10.1191/096120398678920055


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. A. Gomez-Puerta, J. Hernandez-Rodriguez, A. Lopez-Soto, and X. Bosch Antineutrophil Cytoplasmic Antibody-Associated Vasculitides and Respiratory Disease Chest, October 1, 2009; 136(4): 1101 - 1111. [Abstract] [Full Text] [PDF]

				W.-H. Huang, L.-J. Wang, C.-C. Yu, and J.-L. Lin Bilateral renal aneurysms in a chronic hepatitis B patient Nephrol. Dial. Transplant., January 1, 2007; 22(1): 276 - 277. [Full Text] [PDF]

				G Chironi, C Pagnoux, A Simon, M Pasquinelli-Balice, M Del-Pino, J Gariepy, and L Guillevin Increased prevalence of subclinical atherosclerosis in patients with small-vessel vasculitis Heart, January 1, 2007; 93(1): 96 - 99. [Abstract] [Full Text] [PDF]

				G. M. Eschun, S. N. Mink, and S. Sharma Pulmonary Interstitial Fibrosis as a Presenting Manifestation in Perinuclear Antineutrophilic Cytoplasmic Antibody Microscopic Polyangiitis Chest, January 1, 2003; 123(1): 297 - 301. [Abstract] [Full Text] [PDF]

				A. Della Rossa, C. Baldini, A. Tavoni, A. Tognetti, D. Neglia, G. Sambuceti, R. Puccini, C. Colangelo, and S. Bombardieri Churg-Strauss syndrome: clinical and serological features of 19 patients from a single Italian centre Rheumatology, November 1, 2002; 41(11): 1286 - 1294. [Abstract] [Full Text] [PDF]

				R. Durst, N. Goldschmidt, and A. Ben Yehuda Parvovirus B19 infection associated with myelosuppression and cutaneous polyarteritis nodosa Rheumatology, October 1, 2002; 41(10): 1210 - 1212. [Full Text] [PDF]

				L. D. Cranmer, K. J. Warrington, and S. R. Ytterberg 61-Year-Old Man With Dyspnea and Bilateral Foot Drop Mayo Clin. Proc., April 1, 2002; 77(4): 363 - 366. [PDF]

				J. P. Dutz, L. Benoit, X. Wang, D. J. Demetrick, A. Junker, D. de Sa, and R. Tan Lymphocytic vasculitis in X-linked lymphoproliferative disease Blood, January 1, 2001; 97(1): 95 - 100. [Abstract] [Full Text] [PDF]

				C. L. Rochester and R. L. Kradin Case 39-2000- A 47-Year-Old Woman with Multilobar Pulmonary Consolidation N. Engl. J. Med., December 21, 2000; 343(25): 1876 - 1884. [Full Text] [PDF]