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Lupus
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SLE autoantibodies binding to native calf thymus DNA brominated in high salt

Moinuddin

S Arjumand

A Ali

Department of Biochemistry, Faculty of Medicine, A.M.U., Aligarh 202 002, India

Native calf thymus DNA was brominated in high salt to achieve B->Z conformational transition. Ultraviolet and circular dichroism spectroscopic studies point towards the conformational modification of the native DNA. Specific binding of the monoclonal anti-Z-DNA antibody (Z- 22) to the DNA brominated in high salt further confirmed the B->Z conformational isomerization of native DNA. The role of Z-DNA in the etiopathogenesis of systemic lupus erythematosus has been investigated in the light of the binding of naturally occurring human anti-DNA autoantibodies to the induced Z-DNA.

Key Words: systemic lupus erythematosus • bromination • Z-DNA • anti-DNA antibodies • high salt

Lupus, Vol. 7, No. 8, 524-529 (1998)
DOI: 10.1191/096120398678920587
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