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Mucocutaneous disease in Arabs with systemic lupus erythematosus: Clinical expression and relevance to autoantibodies

Department of Internal Medicine in Mafraq Hospital, PO Box 2951, Abu Dhabi, United Arab Emirates

Y H Al Ahmed

Department of Internal Medicine in Mafraq Hospital, Abu Dhabi, United Arab Emirates

Both criterial and non-criterial mucocutaneous manifestations of 42 Arabs with systemic lupus erythematosus are reviewed. Photosensitivity occurred in 40.5%, malar rash in 35.75% and oral ulcers in 26% of patients. Subcutaneous nodules and subcutaneous lupus erythematosus (SCLE) were not seen, and there were few cases of discoid rash (DLE), Raynaud's phenomenon, livedo reticularis and SLE-related sicca and anticardiolipin syndromes. In the clinical relevance of autoantibodies in these patients, there was a significant association between anti-Sm antibodies and oral ulcers (P = 0.033) and, interestingly, between anti-cardiolipin (aCL) antibodies and lack of photosensitivity (P = 0.014). The report also reviews previously presented data on mucocutaneous LE in Arab and non-Arab patients and emphasises the presence of intra-and inter-racial variations of SLE expression including the clinical relevance to autoantibodies.

Key Words: Arab • ethnicity • skin • SLE

Lupus, Vol. 7, No. 8, 535-539 (1998)
DOI: 10.1191/096120398678920569


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