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Lupus, Vol. 7, No. 8, 557-560 (1998)
DOI: 10.1191/096120398678920523

Nervous system lupus mimics limbic encephalitis

J-P Stübgen

Department of Neurology The New York Hospital-Cornell University Medical College, 525 East 68 Street, New York, NY 10021, USA

A 28-year-old woman with systemic lupus erythematosus (SLE) suffered recent onset fever, headache, encephalopathy followed by severe, repeated generalized seizures. Investigations revealed limbic encephalitis. Tests for Herpes simplex encephalitis and paraneoplastic encephalomyelitis were negative. High titers anti-ribosomal-P antibodies in the cerebrospinal fluid (CSF) suggested an association with nervous system lupus. No brain biopsy was performed. Treatment was with anti-seizure, anti-viral, and immunomodulating medication.

Key Words: status epilepticus • limbic encephalitis • nervous system lupus • neurotoxins


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