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Anticardiolipin and anti-ß2glycoprotein-I antibodies in patients with systemic lupus erythematosus: Comparison between Colombians and Spaniards

L R Espinoza

E Mendez

Department of Medicine, Section of Rheumatology, Louisiana State University Medical Center, New Orleans, LA, USA

J F Molina

J Molina

Department of Internal Medicine, Section of Rheumatology, Universidad de Antioquia, Medellín, Colombia

J Ordi-Ros

Department of Internal Medicine, Systemic and Geriatric Diseases Research Laboratory, Vall d'Hebron Hospital, Barcelona, Spain

A E Gharavi

Department of Medicine, Section of Rheumatology, Louisiana State University Medical Center, New Orleans, LA, USA

We studied the prevalence, isotype distribution, and clinical significance of anticardiolipin (aCL) and anti-ß₂glycoprotein I (anti-ß₂) antibodies in two populations of patients with systemic lupus erythematosus (SLE), 160 Colombians and 160 Spaniards. All sera were tested in our laboratory by enzyme-linked immunosorbent assay (ELISA) for IgG, IgM, and IgA aCL, as well as IgG and IgM anti-ß₂GPI. Positive results for at least 1 of the 3 aCL isotypes were found in 40 Colombians (25%) and 55 Spaniards (34%). IgG aCL was the predominant isotype in both populations. Positive results for at least 1 of the anti-ß₂GPI isotypes were found in 34 Colombians (21%) and 29 Spaniards (18%). IgG anti-ß₂GPI was the dominant isotype in Colombians, while IgM was predominant in Spaniards. Positivity for anti-ß₂GPI in aCL-positive patients was present in 77% in the Colombian group and 50% in the Spaniard group. Among Colombians, IgG aCL and anti-ß₂GPI correlated with thrombosis, fetal loss, and thrombocytopenia. Among Spaniards, IgG aCL and IgG anti-ß₂GPI correlated with thrombosis, fetal loss, and livedo reticularis. For detecting thrombosis and fetal loss, aCL ELISA was more sensitive than anti-ß₂GPI in Spaniards, and anti-ß₂GPI ELISA was more specific than aCL in both populations.

Key Words: anticardiolipin antibodies • anti-ß2glycoprotein I antibodies • antiphospholipid syndrome • systemic lupus erythematosus

Lupus, Vol. 8, No. 2, 134-141 (1999)
DOI: 10.1191/096120399678847533


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