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Nodular regenerative hyperplasia of the liver and antiphospholipid antibodies: report of two cases and review of the literature

M Ramos-Casals

Systemic Autoimmune Diseases Unit;Department of Medicine, IDIBAPS, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain

M García-Carrasco

Rheumatology Unit, Hospital de Especialidades del Centro Médico Nacional Instituto Mexicano del Seguro Social ‘General División Manuel Avila Camacho‘, Puebla, México

R Cervera

J Font

Systemic Autoimmune Diseases Unit;Department of Medicine, IDIBAPS, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain

M Bruguera

Liver Unit, Department of Medicine, IDIBAPS, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain

J Rojas-Rodríguez

M Ingelmo

Systemic Autoimmune Diseases Unit;Department of Medicine, IDIBAPS, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain

Nodular regenerative hyperplasia of the liver (NRHL) is a rare disorder characterized by diffuse micronodular transformation of the hepatic parenchyma without fibrous septa between the nodules. This condition appears to be associated in many ocasions with systemic autoimmune diseases. We describe two new patients with NRHL in whom antiphospholipid antibodies (aPL) were detected in their sera and review the few similar cases reported previously. We also discuss the possible relationship between aPL and NRHL and suggest that these antibodies may play a role in the pathogenesis of some cases of NRHL, specially those with an associated antiphospholipid syndrome.

Key Words: nodular regenerative hyperplasia of the liver • antiphospholipid antibodies • antiphospholipid syndrome

Lupus, Vol. 8, No. 2, 160-163 (1999)
DOI: 10.1191/096120399678847515


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