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Antibodies to cardiolipin and ß2-glycoprotein-1 in HTLV-1-associated myelopathy/tropical spastic paraparesis

Department of Medicine, Louisiana State University Medical Center, New Orleans, LA; Cancer Immunology/Immunotherapy, Stanley S. Scott Cancer Center, LSUMC, New Orleans, LA and Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

W A Wilson

Department of Medicine, Louisiana State University Medical Center, New Orleans, LA; Department of Medicine, Section of Rheumatology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, LA, 70112-2822, USA

F Taheri

Department of Medicine, University of the West Indies, Jamaica

E N Barton

OStC Morgan

A E Gharavi

Department of Medicine, Morehouse School of Medicine, Atlanta, GA

Anticardiolipin and anti-ß2GP1 antibodies were measured in 50 patients with HTLV-1-associated Myelopathy-Tropical Spastic Paraparesis (HAM-TSP) and the results were compared with those obtained for 34 HTLV-1-positive and 35 HTLV-1-negative controls, as well as 128 SLE patients. aCL but not anti-ß2GP1 was associated with HTLV-1 infection. aCL was more prevalent than anti-ß2GP1 (32% vs 8%) and was not associated with anti-ß2GP1 in HAM-TSP. IgA was the dominant isotype of aCL and anti-ß2GP1. The data suggest that tin HAM-TSP, IgA aCL are frequent and are associated with HTLV-1 infection.

Key Words: HAM-TSP • anticardiolipin • antiphospholipid • anti b2GP1 • HTLV-1 infection • retrovirus

Lupus, Vol. 8, No. 3, 210-214 (1999)
DOI: 10.1191/096120399678847731


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