This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Diri, E Articles by Wilson, W A Search for Related Content PubMed PubMed Citation Articles by Diri, E Articles by Wilson, W A Social Bookmarking                         What's this?

Antiphospholipid (Hughes') syndrome in African-Americans: IgA aCL and aß2 glycoprotein-I is the most frequent isotype

E Cucurull

A E Gharavi

D Kapoor

E A Mendez

E Scopelitis

Department of Medicine, Section of Rheumatology, Louisiana State University Medical Center, New Orleans, Louisiana, USA

W A Wilson

Department of Medicine, Section of Rheumatology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, Louisiana, 70112-2822, USA

Antiphospholipid (Hughes') syndrome (APS) has not been reported in African-Americans (A-A) as frequently as in other ethnic groups. We describe eight A-A female patients with APS, including two cases of primary APS (PAPS), four with APS secondary to systemic lupus erythematosus (SLE), one with Sjögren's syndrome, and one with overlap connective tissue disease (CTD). Their mean age was 34 y (range 24–47 y). Patients were followed for a mean of 6 y (range 0.3–11 y). During follow up, both anticardiolipin (aCL) and anti-b₂glycoprotein-I (ab₂GPI) antibodies were measured in stored sera by enzyme-linked immunosorbent assay (ELISA). IgA was the most frequent isotype of aCL and ab₂GPI, and co-occurred with the IgM isotype in three of four patients with neurologic manifestations.

Key Words: anticardiolipin antibodies • anti-ß2glycoprotein-I antibodies • antiphospholipid syndrome • African-Americans

Lupus, Vol. 8, No. 4, 263-268 (1999)
DOI: 10.1191/096120399678847812


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Qian, F. Xie, A. W. Gibson, J. C. Edberg, R. P. Kimberly, and J. Wu Functional expression of IgA receptor Fc{alpha}RI on human platelets J. Leukoc. Biol., December 1, 2008; 84(6): 1492 - 1500. [Abstract] [Full Text] [PDF]

				J. Wu, C. Ji, F. Xie, C. D. Langefeld, K. Qian, A. W. Gibson, J. C. Edberg, and R. P. Kimberly Fc{alpha}RI (CD89) Alleles Determine the Proinflammatory Potential of Serum IgA J. Immunol., March 15, 2007; 178(6): 3973 - 3982. [Abstract] [Full Text] [PDF]

				M L Bertolaccini and M A Khamashta Laboratory diagnosis and management challenges in the antiphospholipid syndrome Lupus, March 1, 2006; 15(3): 172 - 178. [Abstract] [PDF]

				I Uthman and M Khamashta Ethnic and geographical variation in antiphospholipid (Hughes) syndrome Ann Rheum Dis, December 1, 2005; 64(12): 1671 - 1676. [Abstract] [Full Text] [PDF]

				J T Merrill Antibodies and clinical features of the antiphospholipid syndrome as criteria for systemic lupus erythematosus Lupus, November 1, 2004; 13(11): 869 - 876. [Abstract] [PDF]

				M. A. Ozturk, I. C. Haznedaroglu, M. Turgut, and H. Goker Current Debates in Antiphospholipid Syndrome: The Acquired Antibody-Mediated Thrombophilia Clinical and Applied Thrombosis/Hemostasis, April 1, 2004; 10(2): 89 - 126. [Abstract] [PDF]

				J.-C. Wasmuth, D. Oliver y Minarro, A. Homrighausen, L. Leifeld, J. K. Rockstroh, T. Sauerbruch, and U. Spengler Phospholipid Autoantibodies and the Antiphospholipid Antibody Syndrome: Diagnostic Accuracy of 23 Methods Studied by Variation in ROC Curves with Number of Clinical Manifestations Clin. Chem., July 1, 2002; 48(7): 1004 - 1010. [Abstract] [Full Text] [PDF]

				V Aguirre, R Cuchacovich, L Barria, H Aris, C Trejo, L Massardo, R Pasten, and L Espinoza Prevalence and isotype distribution of antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus (SLE) Lupus, February 1, 2001; 10(2): 75 - 80. [Abstract] [PDF]

				A Shrivastava, S Dwivedi, A Aggarwal, and R Misra Anti-cardiolipin and anti-beta 2 glycoprotein Iantibodies in Indian patients with systemic lupus erythematosus: association with the presence of seizures Lupus, January 1, 2001; 10(1): 45 - 50. [Abstract] [PDF]