This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Formiga, F Articles by Pujol, R Search for Related Content PubMed PubMed Citation Articles by Formiga, F Articles by Pujol, R Social Bookmarking                         What's this?

Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI

Internal Medicine Service, Hospital de Bellvitge Princeps d'Espanya, L'Hospitalet de Llobregat, Barcelona, Spain; Internal Medicine Service, c/Feixa Llarga s/n, Hospital de Bellvitge Princeps d'Espanya, L'Hospitalet de Llobregat, Barcelona, Spain

I Moga

M Pac

F Mitjavila

A Rivera

Internal Medicine Service, Hospital de Bellvitge Princeps d'Espanya, L'Hospitalet de Llobregat, Barcelona, Spain.

R Pujol

Objective: Systemic lupus erythematosus (SLE) predominantly affects young patients. SLE starting in later life has a clinical presentation different than in younger patients. We have used the SLE Disease Activity Index (SLEDAI) to explore the relationship between age of onset and disease activity.

Methods: We selected all patients controlled in our hospital at the moment of clinical diagnosis of SLE (100 patients; 85 females and 15 males). They were classified in two groups: those with early onset (<50 y) and those with late onset (>50 y) based on their age at the moment of clinical diagnosis of SLE.

Results: In 12 patients the onset of SLE was > 50 y (10 females and two males; mean age 59 y). The early onset patients had significantly higher SLEDAI values at the presentation and during the first year of disease with respect to elderly patients. Antibodies to DNA and hypocomplementemia were detected more often in younger patients.

Conclusion: Our results confirm using SLEDAI, that the lupus of the elderly patients is a distinct clinical subgroup with a milder course of disease.

Key Words: systemic lupus erythematosus • late onset • SLEDAI

Lupus, Vol. 8, No. 6, 462-465 (1999)
DOI: 10.1177/096120339900800609


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M Nikpour, D. Gladman, D Ibanez, and M. Urowitz Variability and correlates of high sensitivity C-reactive protein in systemic lupus erythematosus Lupus, October 1, 2009; 18(11): 966 - 973. [Abstract] [PDF]

				S Appenzeller, D. Pereira, and L. Costallat Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study Lupus, November 1, 2008; 17(11): 1023 - 1028. [Abstract] [PDF]

				M Nikpour, A A Dempsey, M B Urowitz, D D Gladman, and D A Barnes Association of a gene expression profile from whole blood with disease activity in systemic lupus erythaematosus Ann Rheum Dis, August 1, 2008; 67(8): 1069 - 1075. [Abstract] [Full Text] [PDF]

				E. Karoubi Nordon, G. Hayem, F. Mentre, E. Palazzo, S. Legrain, O. Meyer, and P. Raveaud Letter to the Editor: Late onset systemic lupus erythematosus: A new approach Lupus, December 1, 2007; 16(12): 1011 - 1014. [PDF]

				A Mak, C C Mok, W P Chu, C H To, S N Wong, and T C Au Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups Lupus, January 1, 2007; 16(1): 28 - 34. [Abstract] [PDF]

				C C Mok Prognostic factors in lupus nephritis Lupus, January 1, 2005; 14(1): 39 - 44. [Abstract] [PDF]

				C C Mok and C S Lau Pathogenesis of systemic lupus erythematosus J. Clin. Pathol., July 1, 2003; 56(7): 481 - 490. [Abstract] [Full Text] [PDF]