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Disease expression and class II HLA antigens in systemic lupus erythematosus

The University of Toronto, Centre for Prognosis Studies in the Rheumatic Diseases, Ontario; The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Rheumatic Diseases Unit, the Toronto Hospital, Western Division 399 Bathurst St, 1-318, Toronto M5T 2S8, Ontario, Canada

M B Urowitz

The University of Toronto, Centre for Prognosis Studies in the Rheumatic Diseases, Ontario

G A Darlington

University of Toronto, Ontario Cancer Treatment and Research Foundation, Ontario, Canada

The aim of this investigation was to examine the relationship between Class II HLA antigens and disease expression in systemic lupus erythematosus (SLE). HLA-DR and DQ antigen frequency was studied serologically in 217 SLE patients followed prospectively and compared to 320 healthy controls. The relationship between HLA antigens and the presence of disease manifestations, as well as death was investigated in 117 SLE patients enrolled within the first year of their disease. A univariate analysis confirmed the association between HLA-DR3 and SLE. HLA antigen DR1, DR6, DR7, DQw1 and DQw3 were decreased in patient group compared to the controls. A logistic regression model showed a significantly negative association with HLA-DR1, DR6 and DR7, and a positive association with HLA-DR3. The reduced frequency of HLA-DQw1 and DQw3 was maintained using a logistic procedure. Cox Proportional Hazards models revealed no association between HLA-Class II antigens and death. Logistic regression models revealed no associations between central nervous system (CNS) disease nor musculoskeletal manifestations with any of the DR antigens. There was a trend towards a lower frequency of HLA-DR6 in patients with renal involvement and lower prevalence of HLA-DR1 and HLA-DR7 in patients with vasculitis.

Key Words: systemic lupus erythematosus • HLA antigens • disease expression

Lupus, Vol. 8, No. 6, 467-470 (1999)
DOI: 10.1177/096120339900800610


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