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The SLICC/ACR damage index: progress report and experience in the field

University of Toronto, Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Prognosis Studies in The Rheumatic Diseases, University Health Network, Toronto Western Hospital, 399 Bathurst Street 1-318, Toronto, Ontario, M52 2S8, Canada; Tel: (+1) 416 603 5753; Fax: (+1) 416 603 9387

Murray B Urowitz

University of Toronto, Toronto, Ontario, Canada

The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its validation and its use. It is recommended as an outcome measure for longitudinal studies of prognosis and response to new therapies, and as a stratification measure for clinical trials.

Key Words: SLICC/ACR • damage index • prognosis • outcome • SLE

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