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Classification and definition of major flares in SLE clinical trials

Division of Rheumatology, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 7500, Baltimore, MD 21205, USA; Fax: (+1) 410 614 0498; mpetri{at}welchlink.welch,jhu.edu

Jill Buyon

Hospital for Joint Diseases, New York, USA

Mimi Kim

Department of Environmental Medicine, New York Medical Center, New York, USA

Multiple reliable and valid disease activities indices exist and have been used successfully in longitudinal studies. However, the definition of flare, using these intruments, has not been universally decided or accepted. Because flare is one of the three major patterns of lupus activity, it will remain an important outcome measure in both longitudinal and clinical trial studies.

Key Words: systemic lupus erythematosus • flare • disease activity • SLEDAI

Lupus, Vol. 8, No. 8, 685-691 (1999)
DOI: 10.1191/096120399680411281


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