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Lupus
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Successful treatment of lupus with fludarabine

J-F Viallard

Clinique de Medécine Interne, Hôpital Haut-Lévêque, Pessac, France; JF.viallard{at}umr5540.u-bordeaux.fr

P Mercie

I Faure

J-L Pellegrin

B Leng

Clinique de Medecine Interne, Hopital Haut-Leveque, Pessac, France

We describe a 58-year old patient with chronic lymphocytic leukemia (CLL) who developed systemic lupus erythematosus (SLE) with severe joint involvement. Dilated myocardiopathy precluded the use of high corticoid doses and a 15 days of prednisone (I 5mg/d) had no effect on the polyarthritis. Therefore, fludarabine (25mg/M2) was administered for 5 d. One month after the first cycle, fever, muscle stiffness and polyarthritis resolved. A total of 6 cycles were administered. The evolution was complicated by herpes zoster infection and left pneumococcal pneumonia. At this time of writing (July 1999), the patient is symptom free but is profoundly lymphopenic.

Key Words: fludarabine • systemic lupus erythematosus • chronic lymphocytic leukemia

Lupus, Vol. 8, No. 9, 767-769 (1999)
DOI: 10.1191/096120399678840954
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This article has been cited by other articles:


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 LupusHome page
O Y Jones, P J Alexander, A Lacson, F Gok, A Feliz, Y Marikar, C Madivi, J M Jones, and R A Good
Effects of fludarabine treatment on murine lupus nephritis
Lupus, December 1, 2004; 13(12): 912 - 916.
[Abstract] [PDF]


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