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Primary Sjoögren's syndrome in men: clinical and immunological characteristics

Systemic Autoimmune Diseases Unit, Department of Medicine, IDIBAPS (Institut d'Investigacions Biomèdiques "August Pi i Sunyer’), Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain; Unitat de Malalties Autoimmunes Sistèmiques, Hospital Clinic, C/Villarroel, 170, 08036-Barcelona, Catalonia, Spain, Tel: (+ 34) 93 2275774; Fax: (+ 34) 93 2275774; cervera{at}medicina.ub.es

Josep Font

Manuel Ramos-Casals

Systemic Autoimmune Diseases Unit, Department of Medicine, IDIBAPS (Institut d'Investigacions Biomèdiques "August Pi i Sunyer’), Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain

Mario García-Carrasco

Rheumatology Unit, School of Medicine, Benemérita Universidad Autonoma de Puebla, Puebla, Mèxico

Joseé Rosas

Rheumatology Unit, Hospital de la Vila-Joiosa, Alicante, Spain

Rosa Morlà

Francisco J Munóz

Systemic Autoimmune Diseases Unit, Department of Medicine, IDIBAPS (Institut d'Investigacions Biomèdiques "August Pi i Sunyer’), Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain

Antonia Artigues

Lucio Pallarés

Department of Internal Medicine, Hospital Son Dureta, Mallorca, Spain

Miguel Ingelmo

Systemic Autoimmune Diseases Unit, Department of Medicine, IDIBAPS (Institut d'Investigacions Biomèdiques "August Pi i Sunyer’), Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain

Objective: To determine the clinical and immunological characteristics of primary Sjögren' syndrome (SS) in men from a large series of unselected patients with this condition.

Methods: We studied 223 consecutive patients (204 women and 19 men; mean age at onset 53 y, range 15-87 y, mean disease duration 77 months) with primary SS visited in our units. All these patients fulfilled 4 or more of the diagnostic criteria for SS proposed by the European Community Study Group in 1993.

Results: Nineteen (9%) patients were men and they represent the male group described in this paper. Extraglandular manifestations during the course of their disease were present in 10 (53%) of our male patients with primary SS: articular involvement in 4 (21%) patients, interstitial pneumopathy in 3 (16%) and peripheral neuropathy in 2 (11%). ANA were positive in 13 (68%) patients, RF in 5 (31%), anti-Ro/SS-A in 3 (16%) and cryoglobulins in 1/14 (7%). When compared with women, men with primary SS presented a lower prevalence of articular involvement (21% vs 46%, P=0.03, OR 0.32, CI 0.07-0.97).

Conclusion: Although primary SS is typically a disease of middle-aged women, clinicians should note that it may be diagnosed in male patients. Except for a lower prevalence of articular involvement, we could no find any notable differences in clinical and immunological characteristics between male and female patients with primary SS.

Key Words: primary Sjoögren' syndrome • men

Lupus, Vol. 9, No. 1, 61-64 (2000)
DOI: 10.1177/096120330000900111


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