This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Petri, M Search for Related Content PubMed PubMed Citation Articles by Petri, M Social Bookmarking                         What's this?

Detection of coronary artery disease and the role of traditional risk factors in the Hopkins Lupus Cohort

Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 7500, Baltimore, MD 21205, USA Fax: (+1)410 614 0498; mpetri{at}welchlink.welch.jhu.edu

Coronary artery disease (CAD) is a major cause of morbidity and mortality in SLE, including the Hopkins Lupus Cohort. Currently, 9% of the cohort have had clinical evidence (angina or myocardial infarction) of CAD. In our initial prospective study we found that duration of prednisone, hypertension, hyperlipidemia and obesity were risk factors for later CAD. We can now extend that list to include age, male sex, elevated homocysteine, renal insufficiency and antiphospholipid antibodies. Many of the risk factors are amenable to intervention, but the timing of intervention, and the effectiveness of intervention, must be determined.

Key Words: systemic lupus erythematosus • coronary artery disease • atherosclerosis • homocysteine

Lupus, Vol. 9, No. 3, 170-175 (2000)
DOI: 10.1191/096120300678828226


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K.-H. YIU, S. WANG, M.-Y. MOK, G. C. OOI, P.-L. KHONG, K.-F. H. MAK, K.-F. LAM, C.-S. LAU, and H.-F. TSE Pattern of Arterial Calcification in Patients with Systemic Lupus Erythematosus J Rheumatol, October 1, 2009; 36(10): 2212 - 2217. [Abstract] [Full Text] [PDF]

				D Jain and M K Halushka Cardiac pathology of systemic lupus erythematosus J. Clin. Pathol., July 1, 2009; 62(7): 584 - 592. [Abstract] [Full Text] [PDF]

				M. J. Ryan Young Investigator Award Lecture of the APS Water and Electrolyte Homeostasis Section, 2008: The pathophysiology of hypertension in systemic lupus erythematosus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1258 - R1267. [Abstract] [Full Text] [PDF]

				F Cacciapaglia, E. Zardi, G Coppolino, F Buzzulini, D Margiotta, L Arcarese, M Vadacca, A Amoroso, and A Afeltra Stiffness parameters, intima-media thickness and early atherosclerosis in systemic lupus erythematosus patients Lupus, March 1, 2009; 18(3): 249 - 256. [Abstract] [PDF]

				S. R. Sangle, R. J. Davies, M. Mora, M. A. Baron, G. R. V. Hughes, and D. P. D'Cruz Ankle-brachial pressure index: a simple tool for assessing cardiovascular risk in patients with systemic vasculitis Rheumatology, July 1, 2008; 47(7): 1058 - 1060. [Abstract] [Full Text] [PDF]

				E. Alexanderson, A. Gomez-Leon, A. Vargas, J. L. Romero, C. Sierra Fernandez, M. Rodriguez Valero, L. Garcia-Rojas, A. Meave, and M.-C. Amigo Myocardial ischaemia in patients with primary APS: a 13N-ammonia PET assessment Rheumatology, June 1, 2008; 47(6): 894 - 896. [Abstract] [Full Text] [PDF]

				B. Ranchin and S. Fargue Review: New treatment strategies for proliferative lupus nephritis: keep children in mind! Lupus, August 1, 2007; 16(8): 684 - 691. [Abstract] [PDF]

				C. Christodoulou, S. Sangle, and D. P. D'Cruz Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome Rheumatology, June 1, 2007; 46(6): 907 - 910. [Abstract] [Full Text] [PDF]

				S. Chaiamnuay, A. M Bertoli, J. M Roseman, G. McGwin, M. Apte, S. Duran, L. M Vila, J. D Reveille, and G. S Alarcon African-American and Hispanic ethnicities, renal involvement and obesity predispose to hypertension in systemic lupus erythematosus: results from LUMINA, a multiethnic cohort (LUMINAXLV) Ann Rheum Dis, May 1, 2007; 66(5): 618 - 622. [Abstract] [Full Text] [PDF]

				A. Jonsen, B. Gullstrand, N. Guner, A.A. Bengtsson, O. Nived, L. Truedsson, and G. Sturfelt Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus Lupus, April 1, 2007; 16(4): 245 - 253. [Abstract] [PDF]

				C P Chung, A Oeser, I Avalos, P Raggi, and C M Stein Cardiovascular risk scores and the presence of subclinical coronary artery atherosclerosis in women with systemic lupus erythematosus Lupus, September 1, 2006; 15(9): 562 - 569. [Abstract] [PDF]

				G. Moroni, B. Gallelli, S. Quaglini, G. Banfi, E. Rivolta, P. Messa, and C. Ponticelli Withdrawal of therapy in patients with proliferative lupus nephritis: long-term follow-up Nephrol. Dial. Transplant., June 1, 2006; 21(6): 1541 - 1548. [Abstract] [Full Text] [PDF]

				C Christodoulou, M Zain, M L Bertolaccini, S Sangle, M A Khamashta, G R V Hughes, and D P D'Cruz Prevalence of an abnormal ankle-brachial index in patients with antiphospholipid syndrome with pregnancy loss but without thrombosis: a controlled study. Ann Rheum Dis, May 1, 2006; 65(5): 683 - 684. [Full Text] [PDF]

				A Doria, L Iaccarino, P Sarzi-Puttini, F Atzeni, M Turriel, and M Petri Cardiac involvement in systemic lupus erythematosus Lupus, September 1, 2005; 14(9): 683 - 686. [Abstract] [PDF]

				F Tenedios, D Erkan, and M D Lockshin Cardiac involvement in the antiphospholipid syndrome Lupus, September 1, 2005; 14(9): 691 - 696. [Abstract] [PDF]

				M. Bursztyn, N. Sharifi, P. S. Mofrad, L. Smeeth, S. Thomas, and P. Vallance Vascular Events after Acute Infection or Vaccination N. Engl. J. Med., March 17, 2005; 352(11): 1151 - 1153. [Full Text] [PDF]

				M A Baron, M A Khamashta, G R V Hughes, and D P D'Cruz Prevalence of an abnormal ankle-brachial index in patients with primary antiphospholipid syndrome: preliminary data Ann Rheum Dis, January 1, 2005; 64(1): 144 - 146. [Abstract] [Full Text] [PDF]

				J Brodszki, C Bengtsson, T Lanne, O Nived, G Sturfelt, and K Marsal Abnormal mechanical properties of larger arteries in postmenopausal women with systemic lupus erythematosus Lupus, December 1, 2004; 13(12): 917 - 923. [Abstract] [PDF]

				R. Pullmann Jr, M. Skerenova, J. Lukac, J. Hybenova, V. Melus, P. Kubisz, J. Rovensky, and R. Pullmann Factor V Leiden and Prothrombin G20210A Mutations and the Risk of Atherothrombotic Events in Systemic Lupus Erythematosus Clinical and Applied Thrombosis/Hemostasis, July 1, 2004; 10(3): 233 - 238. [Abstract] [PDF]

				R. Bessant, A. Hingorani, L. Patel, A. MacGregor, D. A. Isenberg, and A. Rahman Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus Rheumatology, July 1, 2004; 43(7): 924 - 929. [Abstract] [Full Text] [PDF]

				A Theodoridou, L Bento, D P D'Cruz, M A Khamashta, and G R V Hughes Prevalence and associations of an abnormal ankle-brachial index in systemic lupus erythematosus: a pilot study Ann Rheum Dis, December 1, 2003; 62(12): 1199 - 1203. [Abstract] [Full Text] [PDF]

				E M C Sella, E I Sato, W A Leite, J A O. Filho, and A Barbieri Myocardial perfusion scintigraphy and coronary disease risk factors in systemic lupus erythematosus Ann Rheum Dis, November 1, 2003; 62(11): 1066 - 1070. [Abstract] [Full Text] [PDF]

				C J Edwards, T Y Lian, H Badsha, C L Teh, N Arden, and H H Chng Hospitalization of individuals with systemic lupus erythematosus: characteristics and predictors of outcome Lupus, September 1, 2003; 12(9): 672 - 676. [Abstract] [PDF]

				A. Schattner and M. H. Liang The Cardiovascular Burden of Lupus: A Complex Challenge Arch Intern Med, July 14, 2003; 163(13): 1507 - 1510. [Full Text] [PDF]

				M Lockshin, F Tenedios, M Petri, G McCarty, R Forastiero, S Krilis, A Tincani, D Erkan, M A Khamashta, and Y Shoenfeld Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus report Lupus, July 1, 2003; 12(7): 518 - 523. [Abstract] [PDF]

				S. L. Nuttall, S. Heaton, M. K. Piper, U. Martin, and C. Gordon Cardiovascular risk in systemic lupus erythematosus--evidence of increased oxidative stress and dyslipidaemia Rheumatology, June 1, 2003; 42(6): 758 - 762. [Abstract] [Full Text] [PDF]

				K Manger, B Manger, R Repp, M Geisselbrecht, A Geiger, A Pfahlberg, T Harrer, and J R Kalden Definition of risk factors for death, end stage renal disease, and thromboembolic events in a monocentric cohort of 338 patients with systemic lupus erythematosus Ann Rheum Dis, December 1, 2002; 61(12): 1065 - 1070. [Abstract] [Full Text] [PDF]

				C. Gordon Long-term complications of systemic lupus erythematosus Rheumatology, October 1, 2002; 41(10): 1095 - 1100. [Full Text] [PDF]

				J M Sabio, J D Mediavilla, C Fernandez-Torres, L Aliaga, and J Jimenez-Alonso Risk factors related to hypertension in a Spanish systemic lupus erythematosus cohort Lupus, June 1, 2001; 10(6): 451 - 452. [PDF]