This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pearson, J D Search for Related Content PubMed PubMed Citation Articles by Pearson, J D Social Bookmarking                         What's this?

Normal endothelial cell function

Centre for Cardiovascular Biology & Medicine, King's College London, Guy's Campus, London SE1 1UL, UK

Endothelial cell functions, primarily involving regulated mediator secretion or altered surface protein expression, are vital for normal homeostasis. Endothelial cells secrete the potent vasodilator and anti-platelet agent prostacyclin and nitric oxide, and also the potent vasoconstrictor peptide endothelin-1; they control the selective adhesion and emigration of leukocytes from the bloodstream; and they are the source of circulating von Willebrand factor, tissue plasminogen activator and type 1 plasminogen activator inhibitor. The properties of healthy endothelium ensure that an antithrombotic and anticoagulant balance is maintained in the bloodstream, and provide a tonic vasodilator action that controls blood flow and pressure on a minute-to-minute basis. Disturbances of normal endothelial function are strongly implicated in the pathogenesis of atherosclerosis and autoimmune vasculitic diseases including lupus.

Key Words: endothelium • nitric oxide • prostacyclin • thrombin • leukocyte • platelet • coagulation • fibrinolysis

Lupus, Vol. 9, No. 3, 183-188 (2000)
DOI: 10.1191/096120300678828299


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J Pope An update in pulmonary hypertension in systemic lupus erythematosus - do we need to know about it? Lupus, April 1, 2008; 17(4): 274 - 277. [Abstract] [PDF]

				R. M. Touyz Regulation of Endothelial Nitric Oxide Synthase by Thrombin Hypertension, March 1, 2007; 49(3): 429 - 431. [Full Text] [PDF]

				E. Lopez-Rivera, T. R. Lizarbe, M. Martinez-Moreno, J. M. Lopez-Novoa, A. Rodriguez-Barbero, J. Rodrigo, A. P. Fernandez, A. Alvarez-Barrientos, S. Lamas, and C. Zaragoza Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration PNAS, March 8, 2005; 102(10): 3685 - 3690. [Abstract] [Full Text] [PDF]

				K. K. Ray, D. A. Morrow, C. M. Gibson, S. Murphy, E. M. Antman, E. Braunwald, and for the ENTIRE-TIMI 23 Study Group Predictors of the rise in vWF after ST elevation myocardial infarction: implications for treatment strategies and clinical outcome: An ENTIRE-TIMI 23 substudy Eur. Heart J., March 1, 2005; 26(5): 440 - 446. [Abstract] [Full Text] [PDF]

				A.-Y. Chong, A.D. Blann, and G.Y.H. Lip Assessment of endothelial damage and dysfunction: observations in relation to heart failure QJM, April 1, 2003; 96(4): 253 - 267. [Full Text] [PDF]

				J. Wojta, C. Kaun, G. Zorn, M. Ghannadan, A. W. Hauswirth, W. R. Sperr, G. Fritsch, D. Printz, B. R. Binder, G. Schatzl, et al. C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils Blood, June 28, 2002; 100(2): 517 - 523. [Abstract] [Full Text] [PDF]