This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by George, J Articles by Shoenfeld, Y Search for Related Content PubMed PubMed Citation Articles by George, J Articles by Shoenfeld, Y Social Bookmarking                         What's this?

Autoimmunity in atherosclerosis: lessons from experimental models

Department of Medicine ‘B’ and the Research Unit of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel

A Afek

Institute of Pathology Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

B Gilburd

Department of Medicine ‘B’ and the Research Unit of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel

D Harats

Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Y Shoenfeld

Department of Medicine ‘B’ and the Research Unit of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel; Department of Medicine ‘B’, Sheba Medical Center, Tel-Hashomer 52621, Israel. Tel: (+972) 3 5302652; Fax: (+972) 3 535 2855; shoenfel{at}post,tau,ac.il

The modern view of atherosclerosis is of a chronic inflammatory disorder. In accord with this paradigm, the process of uninhibited influx of fat to the vessel wall results from an ‘adequate’ response to various forms of injury (i.e. turbulence, infections, modified lipoproteins). This idea has been further extended by several groups, to assume that the atherosclerotic lesion can be the target of an autoimmune mediated attack. According to this hypothesis, the site of initiation of the plaque should bear/express the target autoantigen, whereas concomitantly a respective immune response is generated in the periphery. The examples illuminating this notion are ß2GPI as a target autoantigen, HSP60/65 an oxidized-LDL.

Herein we present evidence to support the involvement of autoimmune mechanisms in atherogenesis based on the experience from experimental models and human studies.

Key Words: atherosclerosis • antiphospholipid antibodies • autoimmunity • ß2-glycoprotein I • HSP 60/65 • oxLDL

Lupus, Vol. 9, No. 3, 223-227 (2000)
DOI: 10.1191/096120300678828190


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. B. Reiss, D. W. Wan, K. Anwar, J. T. Merrill, P. A. Wirkowski, N. Shah, B. N. Cronstein, E. S. L. Chan, and S. E. Carsons A BRIEF COMMUNICATION: Enhanced CD36 Scavenger Receptor Expression in THP-1 Human Monocytes in the Presence of Lupus Plasma: Linking Autoimmunity and Atherosclerosis Exp Biol Med, March 1, 2009; 234(3): 354 - 360. [Abstract] [Full Text] [PDF]

				M Szyper-Kravitz, M Harel, B Gilburd, E Trubniykov, Y. Schiffenbauer, and Y Shoenfeld Application of a Static Fluorescence-Based Cytometer: The Cellscan in Clinical Immunology Lupus, July 1, 2006; 15(7): 436 - 441. [Abstract] [PDF]

				N Espinola-Zavaleta, E Alexanderson-Rosas, N Granados, M E. Soto, and M-C Amigo Myocardial perfusion defects in patients with autoimmune diseases: a prospective study. Analysis of two diagnostic tests Lupus, January 1, 2006; 15(1): 38 - 43. [Abstract] [PDF]

				J. M. P. de Godoy, F. Batigalia, M. R. P. de Godoy, A. C. Brandao, and D. R. S. Souza Anticardiolipin Antibodies as a Risk Factor of Atherosclerosis in Intermittent Claudication Angiology, July 1, 2004; 55(4): 357 - 359. [Abstract] [PDF]

				F J Lopez-Longo, N Caro, M I Almoguera, J Olazaran, J C Alonso-Farto, A Ortega, I Monteagudo, C M. Gonzalez, and L Carreno Cerebral hypoperfusion detected by SPECT in patients with systemic lupus erythematosus is related to clinical activity and cumulative tissue damage Lupus, November 1, 2003; 12(11): 813 - 819. [Abstract] [PDF]

				A Doria, Y Shoenfeld, R Wu, P F Gambari, M Puato, A Ghirardello, B Gilburd, S Corbanese, M Patnaik, S Zampieri, et al. Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus Ann Rheum Dis, November 1, 2003; 62(11): 1071 - 1077. [Abstract] [Full Text] [PDF]

				F. Franceschi, A. R. Sepulveda, A. Gasbarrini, P. Pola, N. G. Silveri, G. Gasbarrini, D. Y. Graham, and R. M. Genta Cross-Reactivity of Anti-CagA Antibodies With Vascular Wall Antigens: Possible Pathogenic Link Between Helicobacter pylori Infection and Atherosclerosis Circulation, July 23, 2002; 106(4): 430 - 434. [Abstract] [Full Text] [PDF]

				H. A. Schenkein, C. R. Berry, D. Purkall, J. A. Burmeister, C. N. Brooks, and J. G. Tew Phosphorylcholine-Dependent Cross-Reactivity between Dental Plaque Bacteria and Oxidized Low-Density Lipoproteins Infect. Immun., November 1, 2001; 69(11): 6612 - 6617. [Abstract] [Full Text] [PDF]