This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tam, L S Articles by Tomlinson, B Search for Related Content PubMed PubMed Citation Articles by Tam, L S Articles by Tomlinson, B Social Bookmarking                         What's this?

Hydroxychloroquine has no significant effect on lipids and apolipoproteins in Chinese systemic lupus erythematosus patients with mild or inactive disease

Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong. Tel: (+852) 2632 3133; Fax: (+852) 2637 5396; tamls813{at}yahoo.com

E K Li

Department of Medicine and Therapeutics; The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

C WK Lam

Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

B Tomlinson

Department of Medicine and Therapeutics; The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

Objective: To investigate the effects of hydroxychloroquine (HCQ) in Chinese patients with systemic lupus erythematosus who were either on a low dose of prednisone or not on prednisone.

Methods: 65 consecutive Chinese lupus patients without features of nephritis underwent assessment of the fasting serum lipid profile, including total cholesterol (TC), triglycerides (TG), HDL-cholesteorl (HDL-C), LDL-cholesterol (LDL-C), apolipoprotein A-1 (apo A-1), apolipoprotein B (apo B) and lipoprotein (a) (Lp(a)).

Results: 44/65 (67.7%) patients were on HCQ with a dose of 244 86 mg daily and 34/65 (52.3%) patients were on 4.3 + 2.6 mg daily of prednisone. The percentages of patients taking prednisone and the mean dose in those patients receiving this treatment were not different between the groups with or without HCQ treatment. TG tended to be lower in those patients on HCQ (median and interquartile range) (1.0 (0.7-1.4) mmol/L vs 1.2 (0.8-1.6) mmol/L), but there were no significant differences in TC or other lipid parameters including Lp(a) between the 2 groups of patients with or without HCQ treatment.

Conclusion: HCQ had no significant effect on the serum lipid profile in these lupus patients with mild or inactive disease. This finding probably reflects the low doses of corticosteroid used and a lower background lipid level in this population.

Key Words: systemic lupus erythematosus • fasting lipids • hydroxychloroquine

Lupus, Vol. 9, No. 6, 413-416 (2000)
DOI: 10.1191/096120300678828541


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J.C. Sachet, E.F. Borba, E. Bonfa, C.G.C. Vinagre, V.M. Silva, and R.C. Maranhao Chloroquine increases low-density lipoprotein removal from plasma in systemic lupus patients Lupus, April 1, 2007; 16(4): 273 - 278. [Abstract] [PDF]

				D D'Cruz Antimalarial therapy: a panacea for mild lupus? Lupus, March 1, 2001; 10(3): 148 - 151. [Abstract] [PDF]