This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Perney, P Articles by Blanc, F Search for Related Content PubMed PubMed Citation Articles by Perney, P Articles by Blanc, F Social Bookmarking                         What's this?

Antiphospholipid antibodies in alcoholic liver disease are influenced by histological damage but not by alcohol consumption

Service de Medecine Inteme E, H6pital Saint Eloi, 2 avenue Bertin-Sans, 34295 Montpellier Cedex 5, France. Tel: (+33) 4 67 33 73 30; Fax: (+33) 4 67 33 78 69.

C Biron-Andreani

Laboratoire d'Hematologie, Hopital Saint Eloi, Montpellier, France

Z Joomaye

P Fabbro-Peray

Service de MWdecine Interne E, Montpellier, France

F Quenet

CRLC Val d'Aurelle, Montpellier, France

J F Schved

Laboratoire d'Hematologie, Hopital Saint Eloi, Montpellier, France

F Blanc

Service de MWdecine Interne E, Montpellier, France

Antiphospholipid antibodies (aPL) have been detected in various liver diseases, particularly cirrhosis. The role of alcoholic consumption per se has been suggested. The aim of our study was to assess the prevalence of aPL in patients with alcoholic liver disease at various states and to correlate the presence of aPL with both liver injury and alcoholic consumption.

Three groups were prospectively included. Group A: 74 controls (age-and sex-matched); group B: 46 patients with alcoholic steatosis; group C: 28 patients with alcoholic cirrhosis. For each patient, lupus anticoagulant, anticardiolipin antibodies and anti-j32-glycoprotein I antibodies were tested.

The prevalence of aPL (presence of at least one positive test) was 5% in group A, 20% in group B and 50% in group C (P < 0.04). No correlation appeared between aPL and Child Pugh score in group C. No correlation was found between the presence of aPL and alcohol intake in patients with either steatosis or cirrhosis. Our study confirms that aPL positivity is more frequently encountered in patients with alcoholic liver disease than in controls. Their prevalence increases with the degree of histological damage but not with the level of alcoholic intake.

Key Words: antiphospholipid antibodies • anticardiolipin antibodies • anti-fl2-glycoprotein I antibodies • alcoholic liver disease • alcohol consumption

Lupus, Vol. 9, No. 6, 451-455 (2000)
DOI: 10.1191/096120300678828659


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				I. Uthman and M. Khamashta The abdominal manifestations of the antiphospholipid syndrome Rheumatology, November 1, 2007; 46(11): 1641 - 1647. [Abstract] [Full Text] [PDF]