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Lupus
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Parkinsonism as unusual neurological complication in childhood systemic lupus erythematosus

K L Kwong

Department of Paediatrics, Tuen Mun Hospital, Tsing Chung Koon Road, NIT., Hong Kong, SAR China. Tel: (+852) 24685111; Fax: (+852) 23391729

R Chu

S N Wong

Department of Paediatrics, Tuen Mun Hospital, Hong Kong, SAR China

Parkinsonism complicating systemic lupus erythematosus (SLE) is extremely rare. We report two girls with SLE who developed extrapyramidal parkinsonian features after an initial stormy course. One patient presented with generalized tonic clonic seizure and was then noted to have akinetic mutism and masked face. MRI brain revealed abnormal signals in bilateral basal ganglia and single photon emission computed tomography (SPECT) showed hypoperfusion in the same area. EEG background was slow and disorganized. Symptoms persisted despite high dose intravenous methylprednisolone and cyclophosphamide. Intravenous immunoglobulin (IVIG) was prescribed empirically and was followed by complete recovery. Both EEG and MRI brain were normal on follow-up. The second patient was found unconscious and then developed bradykinesia, mutism and shuffling gait. MRI and SPECT both detected abnormalities in basal ganglia. EEG was slow. Intravenous immunoglobulin was given after methylprednisolone and cyclophosphamide. This was followed by clinical improvement. The pathogenesis of basal ganglia injury in SLE, along with the management of cerebral lupus and the mechanisms of action of IVIG, are discussed.

Key Words: systemic lupus erythematosus • children • Parkinsonism • intravenous immunoglobulin • neurological complications

Lupus, Vol. 9, No. 6, 474-477 (2000)
DOI: 10.1191/096120300678828578
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