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Lupus
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Crossing of antinuclear antibodies and anti-leishmania antibodies

B Granel

J Serratrice

L Swiader

Service de Médecine Interne, CHU Timone, Marseille, France

F Gambarelli

Laboratoire de Parasitologie, CHU Timone, Marseille, France

L Daniel

Service d'Anatomie Pathologique, CHU Timone, Marseille, France

C Fossat

Laboratoire d'Hématologie, CHU Timone, Marseille, France

S Hesse-Bonérandi

Service de Dermatologie, CHU Timone, Marseille, France

X Pache

Service de Médecine Interne, CHU Timone, Marseille, France

P Disdier

Service de Médecine Interne, CHU Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France. Tel: (/ 4) 91 38 60 39; Fax: (/ 4) 91 34 74 01; pdisdier{at}ap-hm.fr

P J Weiller

Service de Médecine Interne, CHU Timone, Marseille, France

Visceral leishmaniasis or Kala-azar is an endemic parasitic infection in Mediterranean countries. We report an interesting case occurring in a 38-year-old woman suffering from systemic lupus erythematosus and secondary antiphospholipid syndrome. In our patient visceral leishmaniasis occurred during high dose-steroids treatment mimicking a flare of lupus. As the lupus resolved under immunosuppressive treatment, a reactivation of visceral leishmaniasis was observed and was confirmed by the successive serological tests which showed crossing of leishmania and antinuclear antibody titers. Our case shows that, faced with fever occurring in lupus patients in an endemic area, visceral leishmaniasis should be searched for before intensifying immunosuppressive treatments.

Key Words: systemic lupus erythematosus • visceral leishmaniasis • antinuclear antibodies • antileishmania antibodies

Lupus, Vol. 9, No. 7, 548-550 (2000)
DOI: 10.1177/096120330000900713
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This article has been cited by other articles:


Home page
 LupusHome page
G Castellino, M Govoni, A L. Monaco, C Montecucco, F Colombo, and F Trotta
Visceral leishmaniasis complicating a connective tissue disease: three case reports from Italy
Lupus, March 1, 2004; 13(3): 192 - 200.
[Abstract] [PDF]


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