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Parvovirus B19 infection associated with the production of antineutrophil cytoplasmic antibody (ANCA) and anticardiolipin antibody (aCL)

T-C Hsu

R-M Chen

Department of Medicine and Institute of Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan

L-I Lin

School of Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan

G J Tsay

Department of Medicine and Institute of Immunology, Chung Shan Medical and Dental College, 110 Sec 1, Chien Kuo N. Road, Taichung 402, Taiwan. Tel: (/ 886) 4 3248160; Fax: (/ 886) 4 4723229; gjt{at}mercury.csmc.edu.tw

We described four patients who had clinical diagnosis of erythema infectiosum and presented with skin rash, polyarthralgia, polyarthritis, and mild fever. Anti-parvovirus B19 IgM and IgG antibodies were found in all four patients and parvovirus B19 DNA was detected in three of the four patients by polymerase chain reaction (PCR) in sera using standard methods. Anticardiolipin antibody (aCL) was positive in three of the four patients included three with anti-b2 glycoprotein I (b2GPI). The immunoglobulin isotype of aCL was found to be IgM. Anti-neutrophil cytoplasmic antibody (ANCA) included three p-ANCA and one c-ANCA was detected in all four patients by indirect immunofluoresence (IIF). Both anti-proteinase 3 (PR3) and anti-myeloperoxidase (MPO) antibodies were found in two patients whom had polyarthritis for more than 6 months. These data indicate parvovirus B19 may be linked to the induction of an autoimmune response.

Key Words: parvovirus B19 infection • ANCA • aCL • autoimmune response

Lupus, Vol. 9, No. 7, 551-554 (2000)
DOI: 10.1177/096120330000900714


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