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Lupus
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Lamotrigine-induced lupus

P Sarzi-Puttini

University Hospital L Sacco, Rheumatology Unit, Department of Internal Medicine, Via G.B. Grassi 74, 20157 Milano, Italy; sarzi{at}tiscalinet.it

B Panni

M Cazzola

S Muzzupappa

M Turiel

Rheumatology Unit, Department of Internal Medicine, University Hospital L Sacco, Milan, Italy

A 57-year-old woman was under treatment for epilepsy with lamotrigine 2 mg/kg/d since 1996. In April 1998 she was admitted to the Rheumatology Unit for arthralgias affecting the small joints of the hands, wrists and knees, erythematosus skin rash and myalgias. She referred a vascular abnormality at the hands exposed to cold, compatible with Raynaud's phenomenon. Serum antinuclear antibodies (ANA) were positive (1:320, speckled pattern); moreover, a positivity for anti-Ro/SSA was observed. Rheumatoid factor was negative, serum complement was normal. LAC and anticardiolipin antibodies were negative. Drug-related lupus diagnosis was made with resolution of symptoms and gradual normalisation of positivity of ANA and anti-Ro/SSA upon lamotrigine withdrawal. To our knowledge, this is the first case report of an association between lamotrigine and the onset of SLE (systemic lupus erythematosus).

Key Words: drug-induced SLE • lamotrigine

Lupus, Vol. 9, No. 7, 555-557 (2000)
DOI: 10.1177/096120330000900715
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