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Autoantibody responses to cardiolipin and DNA in infancy: association with lymphocytic panniculitis

Department of Dermatology, Nara Medical University, Kashihara City, Nara, Japan

Y Uchida

K Taira

Department of Pediatrics, National Nara Hospital, Nara City, Nara, Japan

M Higuchi

Department of Dermatology, Nara Medical University, Kashihara City, Nara, Japan

K Hashimoto

Department of Pediatrics, National Nara Hospital, Nara City, Nara, Japan

A Yoshioka

Department of Pediatrics, Nara Medical University, Kashihara City, Nara, Japan

T Shirai

Department of Dermatology, Nara Medical University, Kashihara City, Nara, Japan

We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double stranded DNA (dsDNA) and anti-single stranded DNA (ssDNA) antibodies. There were no detectable antibodies to small nuclear ribonucleoproteins including Ro/SSA and La/SSB. His mother was consistently seronegative for any of these antibodies. Without corticosteroid therapy, cutaneous lesions resolved and anticardiolipin antibodies, but not anti-dsDNA and ssDNA antibodies, normalized within 16 months after the onset of the disease. Our patient demonstrated an uncommon presentation of aCL related cutaneous manifestation, the presentation with panniculitis being only the third such patient reported in the literature. Of great interest was the appearance of aCL antibodies and skin lesions during very early infancy.

Key Words: anticardiolipin antibodies • anti-DNA antibodies • lymphocytic panniculitis • infancy

Lupus, Vol. 9, No. 8, 637-640 (2000)
DOI: 10.1191/096120300678828721


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