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Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

Department of Rheumatology, University Hospital, Lund, Sweden

G Sturfelt

Department of Rheumatology, University Hospital, S-221 85 Lund, Sweden; Anders.Bengtsson{at}reum.lu.se

L Truedsson

Department of Clinical Microbiology, University Hospital, Lund, Sweden

J Blomberg

Section of Virology, Department of Clinical Microbiology, University Hospital, Uppsala, Sweden

G Alm

H Vallin

Section of Immunology, Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden

L Rönnblom

Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

The objective was to investigate the relation between serum levels of interferon- (IFN-), the activity of an endogenous IFN-a inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN- were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score). The SLE-IIF activity was measured by its ability to induce IFN- production in cultures of normal peripheral blood mononuclear cells. Both serum IFN- and SLE-IIF increased markedly at flare in serially followed patients. The SLEDAI score, levels of anti-dsDNA antibodies and IL-10 correlated positively, and complement components Clq, C3 and leukocytes correlated inversely with serum concentrations of IFN-. The extent of multiple organ involvement correlated with serum IFN-. No relation between concentrations of retroviral peptide binding antibodies and IFN- or SLE-IIF activity was found. The close relationship between disease activity in SLE patients and IFN- serum levels suggests that activation of the type I IFN system might be of importance in the disease process.

Key Words: SLE • interferon-a • retrovirus • SLEDAI • interferon inducer

Lupus, Vol. 9, No. 9, 664-671 (2000)
DOI: 10.1191/096120300674499064


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