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ASE-1: an autoantigen in systemic lupus erythematosus

Department of Anatomy and Cell Biology University of Calgary, Calgary, Alberta, Canada

M Fritzler

Department of Anatomy and Cell Biology University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada

C Whitehead

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Cell Pathways, 782 Electronic Dr, Horsham, PA 19044, USA. rattner{at}ucalgary.ca

L Martin

Department of Anatomy and Cell Biology University of Calgary, Calgary, Alberta, Canada

J B Rattner

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada; Department of Anatomy and Cell Biology, 3330 Hospital Drive NW, T3B 5B7. Tel: / 1403 220 4478; Fax: / 1403 220 0737.

ASE-1 is a 55 kDa nucleolar autoantigen. We show that autoantibodies to this antigen occur at a higher frequency in the sera of patients with SLE than in other systemic rheumatic diseases and that the specificity of ASE-1 as a serum marker of SLE increases as the number of epitopes recognized by the sera increases. Autoantibodies to ASE-1 were temporally associated with autoantibodies to HsEg5 but were not found in conjunction with other known serum markers of SLE. The frequency of antibodies to ASE-1 epitopes in a SLE cohort was approximately the same as anti-dsDNA. However, anti-dsDNA is associated with renal involvement, whereas ASE-1 reactivity shows an association with a history of serositis. We conclude that ASE-1 is correlated with serositis and that ASE-1 should be added to a list of autoantigens that are considered important serological features of SLE.

Key Words: ASE-1 • nucleolus • SLE • serum marker

Lupus, Vol. 9, No. 9, 681-687 (2000)
DOI: 10.1191/096120300670803230


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