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Lupus, Vol. 15, No. 12, 881-885 (2006)
DOI: 10.1177/0961203306070970

Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy

D Micheloud

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

L Nuño

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

M Rodríguez-Mahou

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

S Sánchez-Ramón

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

M C Ortega

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

A Aguarón

Obstretics and Gynecology Department, University General Hospital Gregorio Marañón, Madrid, Spain

E Junco

Nephrology Department, University General Hospital Gregorio Marañón, Madrid, Spain

J Carbone

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

E Fernández-Cruz

Immunology Department, University General Hospital Gregorio Marañón, Madrid, Spain

L Carreño

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain

F J López-Longo

Rheumatology Department, University General Hospital Gregorio Marañón, Madrid, Spain, fjlopezlongo{at}hotmail.com

We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated with a combination of anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin. No flares were observed either in clinical symptoms or in laboratory examinations during pregnancy or after delivery. Her autoantibodies except fluorescent anti-nuclear antibodies were negative. We suggest that a combination of anti-TNF-alpha, plasmapheresis and high-dose intravenous gammaglobulin may be a safe and effective therapy for pregnant patients suffering severe lupus nephritis.

Key Words: systemic lupus erytematosus • pregnancy • etanercept • intravenous gammaglobulin and plasmapheresis.

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 Rheumatology (Oxford)Home page
M. Ostensen, M. Lockshin, A. Doria, G. Valesini, P. Meroni, C. Gordon, A. Brucato, and A. Tincani
Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs
Rheumatology, June 1, 2008; 47(suppl_3): iii28 - iii31.
[Abstract] [Full Text] [PDF]

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